This highly interdisciplinary thesis reports on two innovative photonic biosensors that combine multiple simultaneous measurements to provide unique insights into the activity and structure of surface immobilized biological molecules. In addition, it presents a new silicon photonic biosensor that exploits two cascaded resonant sensors to provide two independent measurements of a biological layer immobilized on the surface. By combining these two measurements, it is possible to unambiguously quantify the density and thickness of the molecular layer; here, the approach's ability to study molecular conformation and conformational changes in real time is demonstrated.
ISBN: | 9783319605005 |
Publication date: | 27th July 2017 |
Author: | José Juan Colás |
Publisher: | Springer an imprint of Springer International Publishing |
Format: | Hardback |
Pagination: | 149 pages |
Series: | Springer Theses |
Genres: |
Biophysics Electrochemistry and magnetochemistry Engineering applications of electronic, magnetic, optical materials Condensed matter physics (liquid state and solid state physics) Scientific standards, measurement etc |