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Nanoscale Imaging and Characterisation of Amyloid Beta

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Nanoscale Imaging and Characterisation of Amyloid Beta Synopsis

This thesis presents a method for reliably and robustly producing samples of amyloid-? (A?) by capturing them at various stages of aggregation, as well as the results of subsequent imaging with various atomic force microscopy (AFM) methods, all of which add value to the data gathered by collecting information on the peptide's nanomechanical, elastic, thermal or spectroscopical properties. 

Amyloid-? (A?) undergoes a hierarchy of aggregation following a structural transition, making it an ideal subject of study using scanning probe microscopy (SPM), dynamic light scattering (DLS) and other physical techniques. By imaging samples of A? with Ultrasonic Force Microscopy, a detailed substructure to the morphology is revealed, which correlates well with the most advanced cryo-EM work. Early stage work in the area of thermal and spectroscopical AFM is also presented, and indicates the promise these techniques may hold for imaging sensitive and complex biological materials. This thesis demonstrates that physical techniques can be highly complementary when studying the aggregation of amyloid peptides, and allow the detection of subtle differences in their aggregation processes.

About This Edition

ISBN: 9783319395333
Publication date:
Author: Claire Louisa TinkerMill
Publisher: Springer an imprint of Springer International Publishing
Format: Hardback
Pagination: 149 pages
Series: Springer Theses
Genres: Spectrum analysis, spectrochemistry, mass spectrometry
Medical research
Condensed matter physics (liquid state and solid state physics)
Neurology and clinical neurophysiology
Nanotechnology