Main Question: G protein coupled receptors are involved in highly efficient and specific activation of signalling pathways. How do GPCR signalling complexes get assembled to generate such specificity? In order to answer this question, we need to understand how receptors and their signalling partners are synthesized, folded and quality-controlled in order to generate functional proteins. Then, we need to understand how each partner of the signalling complex is selected to join a complex, and what makes this assembly possible. GPCRs are known to be able to function as oligomers, what drives the assembly into oligomers and what will be the effects of such organization on specificity and efficacy of signal transduction. Once the receptor complexes are assembled, they need to reach different locations in the cell; what drives and controls the trafficking of GPCR signalling complexes. Finally, defects in synthesis, maturation or trafficking can alter functionality of GPCRs signalling complexes; how can we manipulate the system to make it function normally again? Pharmacological chaperones may just be part of the answer to this question.
| ISBN: | 9789400747647 |
| Publication date: | 17th November 2012 |
| Author: | Denis J Dupré, Terence E Hébert, Ralf Jockers |
| Publisher: | Springer an imprint of Springer Netherlands |
| Format: | Hardback |
| Pagination: | 300 pages |
| Series: | Subcellular Biochemistry |
| Genres: |
Medical research Pharmacology Medicinal chemistry Biochemistry |
Main Question: G protein coupled receptors are involved in highly efficient and specific activation of signalling pathways. How do GPCR signalling complexes get assembled to generate such specificity? In order to answer this question, we need to understand how receptors and their signalling partners are synthesized, folded and quality-controlled in order to generate functional proteins. Then, we need to understand how each partner of the signalling complex is selected to join a complex, and what makes this assembly possible. GPCRs are known to be able to function as oligomers, what drives the assembly into oligomers and what will be the effects of such organization on specificity and efficacy of signal transduction. Once the receptor complexes are assembled, they need to reach different locations in the cell; what drives and controls the trafficking of GPCR signalling complexes. Finally, defects in synthesis, maturation or trafficking can alter functionality of GPCRs signalling complexes; how can we manipulate the system to make it function normally again? Pharmacological chaperones may just be part of the answer to this question.
GPCR Signalling Complexes features in the following genres: Medical research, Pharmacology, Medicinal chemistry, Biochemistry
GPCR Signalling Complexes is available in Hardback
GPCR Signalling Complexes was written by Denis J Dupré, Terence E Hébert, Ralf Jockers and published by Springer an imprint of Springer Netherlands
GPCR Signalling Complexes has 300 pages
Yes it is part of Subcellular Biochemistry series