Bright young men bond in their teens and vow to become doctors to cure the brother of one. His infliction: schizophrenia, cruelly treated at that time. Both qualify and follow opposing sides of the developing science, one rational, one Freudian. This is an impressive work which details their long lives and the study of the early theories of psychiatry. It's beautifully written as one would expect, just, perhaps, a tad too long I felt.