Mitochondria produce the chemical energy necessary for eukaryotic cell functions; hence mitochondria are an essential component of health, playing roles in both disease and aging. More than 80 human diseases and syndromes are associated with mitochondrial dysfunction; this book focuses upon diseases linked to these ubiquitous organelles. Accumulation of mitochondrial DNA damage results in mitochondrial dysfunction through two main pathways. Mutation in mitochondrial DNA causes diseases such as Kearns-Sayre syndrome and Pearson syndrome. Mutation in chromosomal DNA causes diseases such as Parkinson's disease and schizophrenia. These and many other diseases are reviewed in this book.
Key Features
ISBN: | 9781138336087 |
Publication date: | 18th June 2019 |
Author: | Shamim I Ahmad |
Publisher: | CRC Press |
Format: | Hardback |
Pagination: | 480 pages |
Genres: |
Pharmacology Neurology and clinical neurophysiology Biochemistry Molecular biology Cellular biology (cytology) Physiology Endocrinology Palliative medicine Pathology Medicine: general issues |