This detailed book focuses on cutting-edge methods for Parkinson's disease (PD) research, such as the analysis of the prion-like properties of ?-synuclein, mitochondrial functions related to the PINK1-Parkin pathway/CHCHD2, the endolysosome pathway related to LRRK2, VPS35, and ATP13A2 using cultured cells (including patient iPS cells), deep brain stimulation therapy, classic mitochondrial toxins related to PD, and genetic associations and screenings using mammalian and invertebrate genetic models of PD. The collection intends to serve as an introductory protocol book for basic research on PD pathogenesis. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
| ISBN: | 9781071614945 |
| Publication date: | 28th May 2021 |
| Author: | Yuzuru Imai |
| Publisher: | Humana Press an imprint of Springer US |
| Format: | Hardback |
| Pagination: | 217 pages |
| Series: | Methods in Molecular Biology |
| Genres: |
Neurosciences Scientific equipment, experiments and techniques Biology, life sciences |