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Science of Discworld III: Darwin's Watch
Roundworld is in trouble again, and this time it looks fatal. Having created it in the first place, the wizards of Unseen University feel vaguely responsible for its safety. They know the creatures who lived there escaped the impending Big Freeze by inventing the space elevator - they even intervened to rid the planet of a plague of elves, who attempted to divert humanity onto a different time track. But now it's all gone wrong - Victorian England has stagnated and the pace of progress would embarrass a limping snail. Unless something drastic is done, there won't be time for anyone to invent spaceflight and the human race will be turned into ice-pops. Why, though, did history come adrift? Was it Sir Arthur Nightingale's dismal book about natural selection? Or was it the devastating response by an obscure country vicar called Charles Darwin, whose bestselling Theology of Species made it impossible to refute the divine design of living creatures? Either way, it's no easy task to change history, as the wizards discover to their cost. Can the God of Evolution come to humanity's aid and ensure Darwin writes a very different book? And who stopped him writing it in the first place?
Ian Stewart, Jack Cohen, Terry Pratchett (Author), Michael Fenton Stevens, Stephen Briggs (Narrator)
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Breath from Salt: A Deadly Genetic Disease, a New Era in Science, and the Patients and Families Who
'Elaborating on the science as well as the business behind the fight against cystic fibrosis, Trivedi captures the emotions of the families, doctors, and scientists involved in the clinical trials and their 'weeping with joy' as new drugs are approved, and shows how cystic fibrosis, once a 'death sentence,' became, for many, a manageable condition. This is a rewarding and challenging work.' —Publishers Weekly Cystic fibrosis was once a mysterious disease that killed infants and children. Now it could be the key to healing millions with genetic diseases of every type—from Alzheimer's and Parkinson's to diabetes and sickle cell anemia. In 1974, Joey O'Donnell was born with strange symptoms. His insatiable appetite, incessant vomiting, and a relentless cough—which shook his tiny, fragile body and made it difficult to draw breath—confounded doctors and caused his parents agonizing, sleepless nights. After six sickly months, his salty skin provided the critical clue: he was one of thousands of Americans with cystic fibrosis, an inherited lung disorder that would most likely kill him before his first birthday. The gene and mutation responsible for CF were found in 1989—discoveries that promised to lead to a cure for kids like Joey. But treatments unexpectedly failed and CF was deemed incurable. It was only after the Cystic Fibrosis Foundation, a grassroots organization founded by parents, formed an unprecedented partnership with a fledgling biotech company that transformative leaps in drug development were harnessed to produce groundbreaking new treatments: pills that could fix the crippled protein at the root of this deadly disease. From science writer Bijal P. Trivedi, Breath from Salt chronicles the riveting saga of cystic fibrosis, from its ancient origins to its identification in the dank autopsy room of a hospital basement, and from the CF gene's celebrated status as one of the first human disease genes ever discovered to the groundbreaking targeted genetic therapies that now promise to cure it. Told from the perspectives of the patients, families, physicians, scientists, and philanthropists fighting on the front lines, Breath from Salt is a remarkable story of unlikely scientific and medical firsts, of setbacks and successes, and of people who refused to give up hope—and a fascinating peek into the future of genetics and medicine.
Bijal P. Trivedi (Author), Deepti Gupta (Narrator)
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The Loop: How Technology is Creating a World Without Choices and How to Fight Back
This eye-opening narrative journey into the rapidly changing world of artificial intelligence reveals the dangerous ways AI is exploiting the unconscious habits of our minds-and the real threat it poses to humanity. Artificial intelligence is going to change the world as we know it. But the real danger isn't some robot that's going to enslave us: It's our own brain. Our brains are constantly making decisions using shortcuts, biases, and hidden processes-and we're using those same techniques to create technology that makes choices for us. In The Loop, award-winning science journalist Jacob Ward reveals how we are poised to build all of our worst instincts into our AIs, creating a narrow loop where each generation has fewer, predetermined, and even dangerous choices. Taking us on a world tour of the ongoing, real-world experiment of artificial intelligence, The Loop illuminates the dangers of writing dangerous human habits into our machines. From a biometric surveillance state in India that tracks the movements of over a billion people, to a social media control system in China that punishes deviant friendships, to the risky multiple-choice simplicity of automated military action, Ward travels the world speaking with top experts confronting the perils of their research. Each stop reveals how the most obvious patterns in our behavior-patterns an algorithm will use to make decisions about what's best for us-are not the ones we want to perpetuate. Just as politics, marketing, and finance have all exploited the weaknesses of our human programming, artificial intelligence is poised to use the patterns of our lives to manipulate us. The Loop is call to look at ourselves more clearly-our most creative ideas, our most destructive impulses, the ways we help and hurt one another-so we can put only the best parts of ourselves into the thinking machines we create.
Jacob Ward (Author), Jacob Ward (Narrator)
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Age Proof: The New Science of Living a Longer and Healthier Life
Did you know that we can lead longer and healthier lives by making simple changes right now? Professor Rose Anne Kenny has 35 years of experience at the forefront of ageing medicine. In Age Proof, she draws on her own pioneering research and the latest evidence to demystify why we age and shows us that 80% of our ageing biology is within our control: we can not only live longer lives but become happier and healthier deep into our later years. Effortlessly distilling scientific theory into practical advice that we can apply to our everyday lives, Professor Kenny examines the impact that food, genetics, friendships, purpose, sex, exercise and laughter have on how our cells age. This illuminating book will show you the steps you can take to stay younger for longer - and will prove that you really are just as young as you feel.
Professor Rose Anne Kenny, Rose Anne Kenny (Author), Professor Rose Anne Kenny, Rose Anne Kenny (Narrator)
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Drunk Flies and Stoned Dolphins: A Trip Through the World of Animal Intoxication
From the cup of coffee that jumpstarts the day to dangerously addictive drugs, the recreational use of plants with psychoactive properties has a long history among humans. But, as with many things, it turns out that other animals got there first. From parrots to primates, consuming medicinal chemicals is an instinctive behavior that helps countless organisms fight infection and treat disease. But the similarities don't end there: Like us, many creatures also consume substances that have no apparent benefit . . . except for inducing intoxication. In fact, animals have been using drugs for recreational purposes since prehistoric times. We may even have animals to thank for the idea—legend says that coffee was discovered by observing the behavior of goats that had eaten it. In his previous book, Strange Survivors, author and biologist Oné R. Pagán introduced readers to some of the truly bizarre strategies animals use to survive in the cutthroat world of natural selection. Now, in Drunk Flies and Stoned Dolphins, he sheds light on the surprising cravings they indulge when it's time to unwind. In this book, you'll get an eye-opening glimpse into the mind-altering behavior of the non-human members of the animal kingdom, spanning insects to elephants—including the dolphin species that apparently likes to pass around an intoxicating pufferfish as if they were sharing a joint. Combining fascinating science with humor and enthusiasm, Pagán's latest is full of the kind of unforgettable stories and odd facts that you'll find yourself repeating to everyone you meet. From fruit fly happy hour to the evolutionary reasons behind nature's drugs, Drunk Flies and Stoned Dolphins takes you on a trip through the colorful world of animal intoxication—and along the way, explores what this science reveals about the surprising connections between all the world's creatures.
Oné R. Pagán (Author), Eric Jason Martin (Narrator)
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The Folly of Fools: The Logic of Deceit and Self-Deception in Human Life
Whether it's in a cockpit at takeoff or the planning of an offensive war, a romantic relationship or a dispute at the office, there are many opportunities to lie and self-deceive-but deceit and self-deception carry the costs of being alienated from reality and can lead to disaster. So why does deception play such a prominent role in our everyday lives? In short, why do we deceive? In his bold new work, prominent biological theorist Robert Trivers unflinchingly argues that self-deception evolved in the service of deceit-the better to fool others. We do it for biological reasons-in order to help us survive and procreate. From viruses mimicking host behavior to humans misremembering (sometimes intentionally) the details of a quarrel, science has proven that the deceptive one can always outwit the masses. But we undertake this deception at our own peril. The Folly of Fools is an ambitious investigation into the evolutionary logic of lying and the costs of leaving it unchecked.
Robert Trivers (Author), Chris Reilly (Narrator)
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Homo Deus: Breve historia del mañana
Tras el éxito de Sapiens, Yuval Noah Harari vuelve su mirada al futuro para ver hacia dónde nos dirigimos. Bestseller del New York Times con 1 millón de ejemplares vendidos Yuval Noah Harari, autor de Sapiens, un fenómeno internacional unánimemente aclamado por la crítica, regresa con una secuela igualmente original, convincente y provocadora, centrando su atención en el futuro de la humanidad y en nuestra obsesión por convertirnos en dioses. A lo largo del último siglo, la humanidad ha logrado lo imposible frenando la hambruna, la peste y la guerra. Por primera vez en la historia, más personas mueren por obesidad que por pasar hambre y hay más probabilidades de quitarse la vida que de morir en un conflicto bélico o un atentado terrorista. ¿Qué pasará con la democracia cuando Google y Facebook lleguen a conocer nuestros gustos y preferencias políticas mejor que nos conocemos a nosotros mismos? ¿Qué pasará con el estado de bienestar cuando la inteligencia artificial expulse a los individuos del mercado laboral, creando una «clase innecesaria» de humanos? ¿Cómo podremos lidiar con los avances en ingeniería genética? ¿Terminará Silicon Valley por establecer nuevas religiones en lugar de enfocarse a producir únicamente dispositivos inteligentes? Homo Deus explora los proyectos, los sueños y las pesadillas que configurarán el siglo XXI: desde superar la muerte hasta la creación de la inteligencia y la vida artificial. ¿Hacia dónde nos dirigimos? ¿Cómo protegeremos al mundo de nuestros propios poderes destructivos? He aquí una mirada hacia el futuro de la evolución. He aquí Homo Deus. Reseñas: «Yuval Noah Harari, autor del fenómeno Sapiens, reflexiona sobre el futuro de la humanidad en Homo Deus, un libro de prosa inteligente, fresca y libre de prejuicios.» Jorge Wagensberg, Babelia «Aún más legible, incluso más importante que su excelente Sapiens.» Kazuo Ishiguro, Premio Nobel de Literatura «Homo Deus te impactará y te cautivará, pero sobre todo te hará pensar como nunca antes.» Daniel Kahneman, Premio Nobel de Economía «Harari se convierte en una especie de filósofo del futuro que desarrolla las intuiciones de su primera obra [...] un ritmo y una energía que convierten Homo Deus en un libro francamente ameno.» El Cultural «El épico y mundialmente celebrado Sapiens recibe la secuela que necesitaba: una intensa y compulsiva investigación sobre el apocalipsis de la humanidad en un futuro impulsado por la tecnología.» The Guardian «Un libro implacable y fascinante que seguramente se convertirá, y merece ser un éxito de ventas.» Kirkus Review «Un estimulante libro que lleva al lector a profundizar sobre cuestiones de identidad, conciencia e inteligencia.» The Observer «Un brebaje embriagador de ciencia, filosofía y futurismo.» Mail on Sunday «Un estudio brillante, original, estimulante e importante sobre hacia dónde se dirige la humanidad.» Evening Standard
Yuval Noah Harari (Author), Luis David García Márquez (Narrator)
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Superhuman: The Future of Drugs, Bioelectronics, and Genetic Medicine
The next wave of technological change will shape not just our gizmos and gadgets, but our own bodies and minds. Join award-winning historian Michael Bess to learn what to expect from the "Superhuman Revolution." In the near future, developments in bioenhancement technologies will not only alter how we make a living, communicate, and interact with each other, but will offer direct and precise control over our own physical and mental states. People will be able to sculpt their own selfhood over time, reshaping their bodies, augmenting their cognition, micro-managing their emotions and moods, and reconfiguring their character and personality. In this captivating audio series from Michael Bess, author of Our Grandchildren, Redesigned: Life in the Bioengineered Society of the Near Future, you'll explore the promise and peril of tinkering with human bodies and identities. In these 28 illuminating lectures, you'll examine the challenges posed to human civilization by developments in pharmaceuticals, bioelectronics, and genetics. Using an interdisciplinary approach, you'll tackle a series of provocative questions, including: - To what extent can human personhood be modified before it begins to break down? - What would be the likely social and cultural consequences if practices of human redesign were to be widely adopted? - How much can we control the direction in which science, medicine, and technology are taking our civilization? This course is part of the Learn25 collection.
Michael Bess (Author), Michael Bess (Narrator)
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Words Can Change Your Brain: 12 Conversation Strategies to Build Trust, Resolve Conflict, and Increa
In our default state, our brains constantly get in the way of effective communication. They are lazy, angry, immature, and distracted. They can make a difficult conversation impossible. But Andrew Newberg, M.D., and Mark Waldman have discovered a powerful strategy called Compassionate Communication that allows two brains to work together as one. Using brainscans as well as data collected from workshops given to MBA students at Loyola Marymount University, and clinical data from both couples in therapy and organizations helping caregivers cope with patient suffering, Newberg and Waldman have seen that Compassionate Communication can reposition a difficult conversation to lead to a satisfying conclusion. Whether you are negotiating with your boss or your spouse, the brain works the same way and responds to the same cues. The truth, though, is that you don't have to understand how Compassionate Communication works. You just have to do it. Some of the simple and effective takeaways in this book include: • Make sure you are relaxed; yawning several times before (not during) the meeting will do the trick • Never speak for more than 20-30 seconds at a time. After that they other person's window of attention closes. • Use positive speech; you will need at least three positives to overcome the effect of every negative used • Speak slowly; pause between words. This is critical, but really hard to do. • Respond to the other person; do not shift the conversation. • Remember that the brain can only hold onto about four ideas at one time Highly effective across a wide range of settings, Compassionate Communication is an excellent tool for conflict resolution but also for simply getting your point across or delivering difficult news.
Andrew Newberg, Mark Robert Waldman (Author), Mark Robert Waldman (Narrator)
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Land Healer: How Farming Can Save Britain’s Countryside
Brought to you by Penguin. Our relationship with our land is broken: we must heal it. Jake Fiennes is on a mission to change the face of the English countryside. As Conservation Manager at Holkham in Norfolk, one of the country's largest historic country estates, his radical habitat restoration and agricultural work has nurtured its species and risen its crop yields - bringing back wetlands, hedgerows, birds and butterflies over 25,000 acres of land. But this isn't rewilding - there is no 'wild' in Britain anymore. Mass farming, crop science and industrial chemicals have destroyed the majority of our natural landscape and wildlife over the last century. Land Healer is the story of Fiennes's ambition to bring back our flora and fauna - by reclaiming our traditions and trialling new experiments which could restore our symbiosis with our land, and save our shared future. Following the farming year and the natural cycle of the seasons, Land Healer chronicles a life of conservation lived at the edges, and is a manifesto for rethinking our relationship with the natural world before it's too late. 'One of the motive forces behind this new way of looking at the land' - Tony Juniper, chair of Natural England 'Jake Fiennes is changing the face of farming in Britain... a revolutionising force' Isabella Tree © Jake Fiennes 2022 (P) Penguin Audio 2022
Jake Fiennes (Author), Jake Fiennes (Narrator)
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HUMANIFICATION: Go Digital, Stay Human
How Technology will Advance Humanity Towards a More Meaningful Future Imagine being able to spot the next big trend, or being able to predict the next big wave of change. Imagine having a code that gives you the power to invent, predict or harness the next big technology. Humanification is going to help you unlock the DNA of innovation itself, so you can apply it to your life, your business and your community. The story starts with a little girl, a terminal diagnosis and a ticking clock. Join the author as he searches for a cure. Along the way you will discover the seven powerful forces of innovation that are going to change everything in your world within your lifetime. Through a series of stories, research and personal insights, the author reveals how he came to see the world from a totally new perspective. This new vantage point allowed him to uncover a unique wave pattern. Incredibly that wave pattern turned out to be a blueprint for just about every disruptive technology breakthrough. Christian Kromme also made another remarkable breakthrough. He discovered that our manmade technology follows exactly the same evolutionary steps as life itself. By reading this book you will learn to see how the world works at a biological level, a technological level, and a humanity level. You will come to understand how each level is linked, and that knowledge will reveal remarkable new insights into the future. This is a truly remarkable book that no entrepreneur, leader or policy maker can afford to miss. This book shows how technology unites humanity into one big organism. This new insight will change the way you look at technology and its effect on us all us all forever.
Christian Kromme (Author), Derek Botten (Narrator)
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Transformer: The Deep Chemistry of Life and Death
For decades, biology has been dominated by the study of genetic information. Information is important, but it is only part of what makes us alive. Our inheritance also includes our living metabolic network, a flame passed from generation to generation, right back to the origin of life. In Transformer, biochemist Nick Lane reveals a scientific renaissance that is hiding in plain sight-how the same simple chemistry gives rise to life and causes our demise. Lane is among the vanguard of researchers asking why the Krebs cycle, the 'perfect circle' at the heart of metabolism, remains so elusive more than eighty years after its discovery. Transformer is Lane's voyage, as a biochemist, to find the inner meaning of the Krebs cycle-why it is still spinning at the heart of life and death today. Transformer unites the story of our planet with the story of our cells-what makes us the way we are, and how it connects us to the origin of life. Enlivened by Lane's talent for distilling and humanizing complex research, Transformer is a must-listen for anyone fascinated by biology's great mysteries. Life is at root a chemical phenomenon: this is its deep logic.
Nick Lane (Author), Richard Trinder (Narrator)
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