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Audiobooks Narrated by Mike Cooper
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A leading scientist's guide to the way our immune system protects us—but only most of the time
What is our immune system, and how does it work? A vast array of cells, proteins and chemicals spring into action whenever our bodies are damaged, but immunity is not something you can see, touch, or feel. It can fight off malicious bacteria and viruses, locate cancerous growths, and even rewire our brains—but sometimes our own tissues can get caught in its crossfire, with catastrophic consequences.
Humans may be the most disease-ridden animals on the planet. Professor John Trowsdale shows how the immune system protects us, and how our bodies invest huge resources to keep it running. Immunity influences how we age, and controls how we learn to fight off recurring diseases, and how our bodies respond to chronic conditions such as heart disease and dementia. But, in the case of allergies and autoimmune conditions, it can also easily get things wrong.
What the Body Knows is an account of a fascinating phenomenon—one which, for good or for ill, impacts every aspect of our lives.
There are many books claiming to explain the Enlightenment, but most assume that it was a thing. J. C. D. Clark shows what it actually was, namely a historiographical concept.
The Enlightenment: An Idea and Its History provides a critical historical analysis of the Enlightenment in England, Scotland, France, Germany, and the United States from c. 1650 to the present. It argues that the degree of commonality between social and intellectual movements in each—and, more broadly, between the five societies—has been overstated for polemical purposes. Clark shows that the concept of 'the Enlightenment' was not widely adopted in those societies until the mid-twentieth century; indeed, that it was unknown in the eighteenth. Without the concept, people at the time were unable to act in ways that would have created the Enlightenment as a coherent movement. Since the conventional account has held that the Enlightenment was a phenomenon, the idea could be used as a component of what has been called a 'civil religion': a summing up of the myths of origin, aims, and essential values of a society from which dissent is not permitted. An appreciation that it was instead a historiographical concept undermines, in turn, the idea that there was any great transition to what came to be called 'modernity'.
This introduction to the philosophy of medicine surveys the landscape of western philosophy as it pertains to healthcare in an accessible way. Written by a doctor for doctors and other health professionals, framing the 'toolbox' of philosophy within the community of medicine, it encourages examination of the implicit assumptions made in the construction of medical knowledge and practice.
Taking the listener step by step through the concepts that underpin modern philosophy, they will be challenged to reflect upon the premises within clinical practice which might benefit from scrutiny and challenge, including the nature of scientific knowledge, the limits of our biomedical model, the cultural and relational context, and the failure to recognize or manage adequately the fact/value distinction in medicine and healthcare.
The book is an ideal textbook for students of medicine and medical philosophy and will also be of interest to bioethicists, medical sociologists, clinical commissioners, and to practicing clinicians in medicine and the allied health professions seeking to improve their understanding of philosophy and ethics and sharpen their critical thinking skills.
Simon Schama explores the mysterious contradictions of the Dutch nation that invented itself from the ground up, attained an unprecedented level of affluence, and lived in constant dread of being corrupted by happiness. Drawing on a vast array of period documents and sumptuously reproduced art, Schama recreates in precise detail a nation's mental state. He tells of bloody uprisings and beached whales, of the cult of hygiene and the plague of tobacco, of thrifty housewives and profligate tulip-speculators. He tells us how the Dutch celebrated themselves and how they were slandered by their enemies.
Over the last decade, scientists have discovered the importance and widespread presence in the body of a remarkable family of proteins known as prion proteins. Research links various types of prion proteins to neurodegenerative diseases such as Parkinson's and Alzheimer's—and this has fueled the search for new drugs that could halt the progression of these terrible disorders. Other discoveries have revealed the essential roles prion proteins play in memory and immunity, and the part they may have played in the beginnings of life on our planet.
Brahic, a leading researcher on diseases of the central nervous system, first describes the discovery of prions and their role in infection, beginning with early work on the animal disease scrapie and a mysterious human illness in New Guinea, apparently transmitted by cannibalism. Prion proteins were then revealed as the cause of other illnesses, from 'mad cow' disease and its human counterpart, Creutzfeldt-Jakob disease, to such noninfectious brain disorders as Parkinson's and Alzheimer's. While the prion proteins responsible for diseases are definitively 'bad,' Brahic also explains that these abnormal prions are rare exceptions. Most of the time, prion proteins actually serve 'good' and vital functions—and they may even have been present at the origin of life itself.
Forged during the tumultuous aftermath of Partition in 1947, the Inter-Services Intelligence Directorate (ISI) has grown to become the preeminent intelligence service in Pakistan. Its capabilities are comprehensive, its remit covers both foreign and domestic intelligence, and it is one of the most feared and respected agencies of the Global South.
Pakistan's ISI provides an up-to-date and detailed introduction to the ISI and its historical evolution. The narrative is rooted in a deep and wide-ranging contextualization of the state of Pakistan and its security environment. The story is one of an agency that grew from humble beginnings into an extremely capable and robust force at the heart of power in the state. The ISI utilizes broad human intelligence networks and employs covert action and support for militants, particularly in its rivalry with India. As a crucial intelligence partner for the West during the Cold War and into the contemporary era, the ISI has been both an essential ally and problematic partner. The shadow of this agency continues to loom over Pakistan's democratic institutions.
This book will appeal to students, scholars, and general listeners interested in intelligence and the politics and history of South Asia.
The dramatic biography of a slaveship turned freedom-fighter—which brings new insights into Britain's involvement in the end of the trade in enslaved people
In 1827 the Royal Navy purchased a Baltimore clipper and renamed her the Black Joke. Assigned to the Preventative Squadron, she patrolled the west coast of Africa and freed 3,692 captives from enslavement. Beloved by seafarers and celebrated by the public, the Black Joke would become the most famous weapon in the campaign for abolition.
But in her previous life as the Henriqueta, the Black Joke had been a slave ship.
Through the experiences of slavers and abolitionists, captives and crew, Stephen Taylor charts the vessel's extraordinary double life. As the Henriqueta she operated as an engine of atrocity, trafficking over 3,000 captives to plantations in Brazil. But subsequently manned by British seamen and Liberian Kru, the Black Joke became the scourge of Spanish and Brazilian slavers. She did so despite limited resources, neglect, and even obstruction by the authorities at home.
Taylor offers a gripping account of the world of the transatlantic trade, through the eyes of its perpetrators—and those who sought its end.
Following the discovery of the Higgs boson, Frank Close has produced this major revision to his classic and compelling introduction to the fundamental particles that make up the universe. Frank Close takes us on a journey into the atom to examine known particles such as quarks, electrons, and the ghostly neutrino, and explains the key role and significance of the Higgs boson. Along the way he provides fascinating insights into how discoveries in particle physics have actually been made, and discusses how our picture of the world has been radically revised in the light of these developments. He concludes by looking ahead to new ideas about the mystery of antimatter and massive neutrinos, and to what the next fifty years of research might reveal about the nature of the Higgs field which molds the fundamental particles and forces.
By early morning of June 30, 1860, a large crowd began to congregate in front of Oxford University's brand-new Museum of Natural History. The occasion was the annual meeting of the British Association for the Advancement of Science, and the subject of discussion was Charles Darwin's new treatise: fact or fiction?
Darwin claimed to have solved 'that mystery of mysteries,' introducing a logical explanation of the origin of species-how they adapted, even transmogrified, through natural selection. At stake, on that summer's day of spirited debate, was the very foundation of modern biology, not to mention the future of the church. Without fear of exaggeration, Darwin's thesis would forever change our understanding of the life sciences and the natural world. And yet the author himself was nowhere to be found in the debate hall-instead, he was miles away, seeking respite from a spate of illnesses that had plagued him for much of his adult life.
In Origin Story, medical historian Howard Markel recounts the two-year period (1858 to 1860) of Darwin's writing of On the Origin of Species through its spectacular success and controversy. Simultaneously, Markel delves into the mysterious health symptoms Darwin developed, combing the literature to emerge with a cogent diagnosis of a case that has long fascinated medical historians.
A masterful and witty account of Britain's culinary heritage.
This a revised and updated edition of an award-winning book, recognized as the authoritative work on the subject of British food. It is a breathtaking attempt to trace the changes to and influences on food in Britain from the Black Death, through the Enclosures, the Reformation, the Industrial Revolution, the rise of Capitalism to the present day.
There has been a recent wave of interest in food culture and history and Colin Spencer's masterful account of Britain's culinary history is a celebrated contribution to the genre. There has never been such an exciting, broad-scoped history of the food of these islands. It should remind us all of our rich past and the gastronomic importance of British cuisine.
Lenin's work and influence have often been written off as no longer relevant, and many today consider this to be so. Lenin has, they claim, had his day, even though he is still revered in China, the world's most populous country. However, Lenin, like his mentor Marx, has had a tendency to rise from apparent decline and oblivion to renewed force and influence.
This study examines the key elements of Lenin's life and career, the consolidation of his ideas into the doctrines of 'Leninism,' the influence of Leninism in promoting revolutionary movements around the globe, and the currently disputed issue of whether his ideas still have any relevance today. In particular, while considering his views on the role of the revolutionary party, often seen as the centerpiece of his theory and practice, this account identifies the root of Lenin's global influence in his opposition to capitalist imperialism and as a bedrock foundation for the opposition of many to fascism and associated ideologies. While recognizing that Lenin's reputation has reached its lowest point, not least in his home country where his legacy is reviled by Vladimir Putin and other contemporary leaders, the book concludes by weighing up the contemporary arguments of those who believe that Lenin still lives.
